Please see the Editorial Comment by Nicholas M. Beckmann discussing this article.


Musculoskeletal interventional oncology is an emerging field that addresses the limitations of conventional therapies for bone and soft-tissue tumors. The field's growth has been driven by evolving treatment paradigms, expanding society guidelines, mounting supportive literature, technologic advances, and cross-specialty collaboration with medical, surgical, and radiation oncology. Safe, effective, and durable pain palliation, local control, and stabilization of musculoskeletal tumors are increasingly achieved through an expanding array of contemporary minimally invasive percutaneous image-guided treatments, including ablation, osteoplasty, vertebral augmentation (with or without mechanical reinforcement via implants), osseous consolidation via percutaneous screw fixation (with or without osteoplasty), tumor embolization, and neurolysis. These interventions may be used for curative or palliative indications and can be readily combined with systemic therapies. Therapeutic approaches include the combination of different interventional oncology techniques as well as the sequential application of such techniques with other local treatments, including surgery or radiation. This article reviews the current practice of interventional oncology treatments for the management of patients with bone and soft-tissue tumors with a focus on emerging technologies and techniques.


Musculoskeletal interventional oncology is an emerging field driven by evolving treatment paradigms, expanding society guidelines, mounting supportive literature, technologic advances, and cross-specialty collaborations.
Musculoskeletal interventional oncology techniques include ablation, osteoplasty, vertebral augmentation (with possible reinforcement via implants), osseous consolidation via percutaneous screw fixation, tumor embolization, and neurolysis.
The expanding array of minimally invasive image-guided treatments is increasingly used to provide safe, effective, and durable pain palliation and local control of musculoskeletal tumors.

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Information & Authors


Published In

American Journal of Roentgenology
Pages: 503 - 516
PubMed: 37222277


Submitted: February 1, 2023
Revision requested: February 13, 2023
Revision received: April 19, 2023
Accepted: May 15, 2023
Version of record online: May 24, 2023


  1. ablation
  2. musculoskeletal intervention
  3. vertebral augmentation



Brandon M. Key, MD [email protected]
Department of Radiology, Division of Vascular & Interventional Radiology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Rm 2803, Milwaukee, WI 53226.
Matthew R. Callstrom, MD, PhD
Department of Radiology, Division of Vascular & Interventional Radiology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Rm 2803, Milwaukee, WI 53226.
Dimitrios Filippiadis, MD
Department of Diagnostic and Interventional Radiology, University General Hospital “Attikon” Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Department of Radiology, Mayo Clinic, Rochester, MN.


Address correspondence to B. M. Key ([email protected], @bkeymd).
Version of record: Aug 9, 2023
B. M. Key is a consultant for Siemens Healthineers, and M. R. Callstrom is a consultant for Boston Scientific. The remaining author declares that there are no other disclosures relevant to the subject matter of this article.

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